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Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

ID Screen® CCHF Double Antigen Multi-species


Double antigen ELISA for the detection of antibodies against Crimean-Congo haemorrhagic fever virus (CCHFV) in cattle, sheep, goats or other susceptible species, including humans*

*For research use only on human samples






  • The only commercial ELISA for the detection of CCHFV antibodies in multiple species
  • Field-proven, reliable results
    • Excellent specificity (100%) and sensitivity (98.9 %) across multiple species
    • High agreement with VNT, and superior analytical sensitivity with respect to the Immunofluorescence Assay (IFA)
    • Proven absence of cross-reactions with Hazara virus, Dugbe virus, and Nairobi Sheep Disease Virus
  • Convenient and flexible
    • Recombinant-based ELISA means that testing may take place outside of high containment facilities
    • Ready-to-use reagents

Method :

Double antigen ELISA

Species :

Ruminants and other susceptible species. For research use only on human samples: see References.

Specimens :

Serum, plasma and blood filter paper samples

Conjugate :

Freeze-dried recombinant CCHFV nucleoprotein-HRP conjugate (concentrated 10X)

Product reference

Kit format


Plate format

CCHFDA-2P 2 plates 192 12 x 8-well strips
CCHFDA-5P 5 plates 480 12 x 8-well strips

Download the summary of the product external references here

1. Frías M., Cuadrado-Matías R. et al. (2022). The spatial pattern of human exposure to Crimean–Congo haemorrhagic fever virus is not consistent with red deer-based risk predictions. Transboundary and Emerging Diseases, 1–7

2. Lado S., Futas J. et al. (2022). Crimean–Congo Hemorrhagic Fever Virus Past Infections Are Associated with Two Innate Immune Response Candidate Genes in Dromedaries. Cells, 11, 8

3. Altaliby M. A. S., Esmaeel S. A et al. (2021). Seroprevalence Of Crimean-Congo Haemorrhagic Fever In Sheep And Goats In Iraq Bulgarian. Journal of Veterinary Medicine, ISSN 1311-1477

4. Balinandi S., von Brömssen C. et al. (2021). Serological and molecular study of Crimean-Congo Hemorrhagic Fever Virus in cattle from selected districts in Uganda. Journal of Virological Methods 290 114075

5. Blanco-Penedo I., Obanda,V. et al. (2021). Seroepidemiology of Crimean-Congo Hemorrhagic Fever Virus (CCHFV) in Cattle across Three Livestock Pastoral Regions in Kenya. Dairy 2, 425–434

6. Camp J.V., Weidinger P. et al. (2021). Association of Dromedary Camels and Camel Ticks with Reassortant Crimean-Congo Hemorrhagic Fever Virus, United Arab Emirates. Emerging Infectious Diseases Vol. 27, No. 9

7. Cuadrado-Matias R., Casades-Marti L. et al. (2021). The spatiotemporal dynamics of Crimean-Congo haemorrhagic fever virus in enzootic Iberian scenarios. Poster presented at the Virtual 69th WDA /14th EWDA 2021 Joint Conference Cuenca, Spain

8. Esmaeel S.A., Hussain K.J. et al. (2021). Seroprevalence of Crimean Congo Hemorrhagic Fever in cows by ELISA in Mosul city. Iraqi Journal of Veterinary Sciences, Vol. 35, No. 4 (803-807)

9. Espunyes J., Cabezón O. et al. (2021). Hotspot of Crimean-Congo Hemorrhagic Fever Virus Seropositivity in Wildlife, Northeastern Spain. Emerging Infectious Diseases Vol. 27, No. 9

10. Hartlaub J., Daodu O.B. et al. (2021). Cross-Reaction or Co-Infection? Serological Discrimination of Antibodies Directed against Dugbe and Crimean-Congo Hemorrhagic Fever Orthonairovirus in Nigerian Cattle. Viruses 13, 1398

11. Hartlaub J., Keller M. et al.(2021). Deciphering Antibody Responses to Orthonairoviruses in Ruminants Microorganisms 2021, 9, 1493

12. Khbou M.K., Romdhane R. et al. (2021). Presence of antibodies to Crimean Congo haemorrhagic fever virus in sheep in Tunisia, North Africa. VetMed Sci. 1–7

13. Negredo A., Sánchez-Ledesma M. et al. (2021). Retrospective Identification of Early Autochthonous Case of Crimean-Congo Hemorrhagic Fever, Spain, 2013. Emerging Infectious Diseases Vol. 27, No. 6

14. Obanda V., Agwanda B. et al. (2021). Livestock Presence Influences the Seroprevalence of Crimean Congo Hemorrhagic Fever Virus on Sympatric Wildlife in Kenya. Vector-Borne And Zoonotic Diseases, Volume 21, Number 10

15. Phonera M. C., Simuunza M.C. et al. (2021). Seroprevalence and Risk Factors of Crimean-Congo Hemorrhagic Fever in Cattle of Smallholder Farmers in Central Malawi. Pathogens 10, 1613

16. Zouaghi K., Bouattour, A. et al. (2021). First Serological Evidence of Crimean-Congo Hemorrhagic Fever Virus and RiftValley Fever Virus in Ruminants in Tunisia. Pathogens, 10, 769

17. Bouaicha F., Eisenbarth A. et al. (2020). Epidemiological investigation of Crimean-Congo haemorrhagic fever virus infection among the one-humped camels (Camelus dromedarius) in southern Tunisia Ticks and Tick-borne Diseases. Ticks and Tick-borne Diseases, Vol 12, Issue 1

18. Grech-Angelini S., Lancelot. R. et al. (2020). Crimean-Congo Hemorrhagic Fever Virus Antibodies among Livestock on Corsica, France, 2014–2016. Emerging Infectious Diseases; 26(5):1041-1044

19. Hartlaub J., von Arnim F. et al.(2020). Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV. Microorganisms 8, 1927

20. Mangombi J.B., Roqueplo C. et al.(2020). Seroprevalence of Crimean-Congo Hemorrhagic Fever in Domesticated Animals in Northwestern Senegal. Vector-Borne And Zoonotic Diseases, DOI: 20. 10.1089/vbz.2019.2592

21. Zohaib A., Saqib M. et al. (2020). Crimean-Congo Hemorrhagic Fever Virus in Humans and Livestock, Pakistan, 2015–2017.Emerging Infectious Diseases 26 (4)

22. Sas M.A., Comtet L. et al. (2018) A novel double-antigen sandwich ELISA for the species-independent detection of Crimean-Congo hemorrhagic fever virus-specific antibodies Antiviral Research 151, 24-26

Associated products

Internal reference material

Freeze-dried immunized goat serum containing antibodies against CCHFV. Read more