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Home   »   Products   »   Veterinary diagnostics   »     »   Crimean-Congo Hemorrhagic Fever Virus (CCHFV)   »   ID Screen® CCHF Double Antigen Multi-species
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Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

ID Screen® CCHF Double Antigen Multi-species

ELISA

Double antigen ELISA for the detection of antibodies against Crimean-Congo haemorrhagic fever virus (CCHFV) in cattle, sheep, goats or other susceptible species, including humans*

*For research use only on human samples

Advantages

Specifications

Format

References

Downloads

  • The only commercial ELISA for the detection of CCHFV antibodies in multiple species
  • Field-proven, reliable results
    • Excellent specificity (100%) and sensitivity (98.9 %) across multiple species
    • High agreement with VNT, and superior analytical sensitivity with respect to the Immunofluorescence Assay (IFA)
    • Proven absence of cross-reactions with Hazara virus, Dugbe virus, and Nairobi Sheep Disease Virus
  • Convenient and flexible
    • Recombinant-based ELISA means that testing may take place outside of high containment facilities
    • Ready-to-use reagents

Method :

Double antigen ELISA

Species :

Ruminants and other susceptible species. For research use only on human samples: see References.

Specimens :

Serum, plasma and blood filter paper samples

Conjugate :

Freeze-dried recombinant CCHFV nucleoprotein-HRP conjugate (concentrated 10X)

Product reference

Kit format

Reactions

Plate format

CCHFDA-2P 2 plates 192 12 x 8-well strips
CCHFDA-5P 5 plates 480 12 x 8-well strips

Download the summary of the product external references here

RUMINANTS

  1. Atim S.A. et al. (2023). Prevalence of Crimean-Congo haemorrhagic fever in livestock following a confirmed human case in Lyantonde district, Uganda. Parasites & Vectors, 16(1), 1-10.
  2. Babaoglu A. R. et al. (2023). Crimean-Congo Hemorrhagic Fever Virus Infection in Domestic Ruminants in Van Province, a Non-endemic Region in Turkey. Indian Journal of Animal Research, 1, 6.
  3. Matthews J. et al. (2023). Serological Prevalence of Crimean–Congo Hemorrhagic Fever Virus Infection in Small Ruminants and Cattle in The Gambia. Pathogens, 12, 749.
  4. Simo Tchetgna H. et al. (2023). Molecular and serological evidence of Crimean-Congo hemorrhagic fever orthonairovirus prevalence in livestock and ticks in Cameroon. Front. Cell. Infect. Microbiol. 13:1132495.
  5. Bratuleanu B. et al. (2022). Seroprevalence of Crimean-Congo Hemorrhagic Fever Among Small Ruminants from Southern Romania. Vector-Borne and Zoonotic Diseases, 22(7), 397-401.
  6. Duscher G. G. et al. (2022). Hyalomma spp. in Austria—The Tick, the Climate, the Diseases and the Risk for Humans and Animals. Microorganisms, 10(9), 1761.
  7. Dzikwi-Emennaa A.A. et al. (2022). Detection of Crimean-Congo Hemorrhagic Fever Virus Antibodies in Cattle in Plateau State, Nigeria. Viruses 2022, 14, 2618.
  8. Fanelli A. et al. (2022). First serological evidence of Crimean–Congo haemorrhagic fever virus in transhumant bovines in Italy. Transboundary and Emerging Diseases.
  9. González Gordon L. et al. (2022). Seroepidemiology of Crimean-Cong Haemorrhagic Fever among cattle in Cameroon: Implications from a One Health perspective. PLoS Neglected Tropical Diseases, vol. 16, no. 3, e0010217.
  10. Lule S. A. et al. (2022). Widespread exposure to Crimean-Congo haemorrhagic fever in Uganda might be driven by transmission from Rhipicephalus ticks: Evidence from cross-sectional and modelling studies. Journal of Infection, 85(6), 683-692.
  11. Lysholm S. et al. (2022). Seroepidemiology of selected transboundary animal diseases in goats in Zambia. Preventive Veterinary Medicine, 206, 105708.
  12. Satrovic L. et al. (2022). First evidence of Crimean‐Congo haemorrhagic fever virus circulation in Bosnia and Herzegovina. Veterinary Medicine and Science, 8(3), 1271-1275.
  13. Zhabari Z. and Xhekaj B. (2022). Serological data suggest the spread of Crimean-Congo hemorrhagic fever virus in domestic animals in Kosovo-a short communication. Veterinarski arhiv, 92(2), 155-160.
  14. Altaliby M. A. S. et al. (2021). Seroprevalence Of Crimean-Congo Haemorrhagic Fever In Sheep And Goats In Iraq. Bulgarian Journal of Veterinary Medicine, ISSN 1311-1477.
  15. Balinandi S. et al. (2021). Serological and molecular study of Crimean-Congo Hemorrhagic Fever Virus in cattle from selected districts in Uganda. Journal of Virological Methods 290, 114075.
  16. Blanco-Penedo I. et al. (2021). Seroepidemiology of Crimean-Congo Hemorrhagic Fever Virus (CCHFV) in Cattle across Three Livestock Pastoral Regions in Kenya. Dairy 2, 425–434.
  17. Esmaeel S.A. et al. (2021). Seroprevalence of Crimean Congo Hemorrhagic Fever in cows by ELISA in Mosul city. Iraqi Journal of Veterinary Sciences, Vol. 35, No. 4 (803-807).
  18. Hartlaub J. et al. (2021). Cross-Reaction or Co-Infection? Serological Discrimination of Antibodies Directed against Dugbe and Crimean-Congo Hemorrhagic Fever Orthonairovirus in Nigerian Cattle. Viruses 13, 1398.
  19. Hartlaub J. et al. (2021). Deciphering Antibody Responses to Orthonairoviruses in Ruminants. Microorganisms 2021, 9, 1493.
  20. Khbou M.K. et al. (2021). Presence of antibodies to Crimean Congo haemorrhagic fever virus in sheep in Tunisia, North Africa. VetMed Sci. 1–7.
  21. Obanda V. et al. (2021). Livestock Presence Influences the Seroprevalence of Crimean Congo Hemorrhagic Fever Virus on Sympatric Wildlife in Kenya. Vector-Borne And Zoonotic Diseases, Volume 21, Number 10.
  22. Phonera M. C. et al. (2021). Seroprevalence and Risk Factors of Crimean-Congo Hemorrhagic Fever in Cattle of Smallholder Farmers in Central Malawi. Pathogens 10, 1613.
  23. Zouaghi K. et al. (2021). First Serological Evidence of Crimean-Congo Hemorrhagic Fever Virus and Rift Valley Fever Virus in Ruminants in Tunisia. Pathogens, 10-769.
  24. Grech-Angelini S. et al. (2020). Crimean-Congo Hemorrhagic Fever Virus Antibodies among Livestock on Corsica, France, 2014–2016. Emerging Infectious Diseases; 26(5):1041-1044.
  25. Hartlaub J. et al. (2020). Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV. Microorganisms 8, 1927.

CAMELIDS

  1. Lado S. et al. (2022). Crimean–Congo Hemorrhagic Fever Virus Past Infections Are Associated with Two Innate Immune Response Candidate Genes in Dromaderies. Cells, 11-8.
  2. Camp J.V. et al. (2021). Association of Dromedary Camels and Camel Ticks with Reassortant Crimean-Congo Hemorrhagic Fever Virus, United Arab Emirates. Emerging Infectious Diseases, Vol. 27, No. 9.
  3. Bouaicha F. et al. (2020). Epidemiological investigation of Crimean-Congo haemorrhagic fever virus infection among the one-humped camels (Camelus dromedarius) in southern Tunisia. Ticks and Tick-borne Diseases, Vol 12, Issue 1.
  4. Zohaib A. et al. (2020). Crimean-Congo Hemorrhagic Fever Virus in Humans and Livestock, Pakistan, 2015–2017. Emerging Infectious Diseases 26 (4).

DOGS AND HORSES

  1. Vila M. et al. (2023). Zoonotic findings of Hyalomma marginatum in northwestern Spain: horse serological response and human captures. Poster presented at the EVPC meeting, 29-30 June 2023, Maison-Alfort, France.
  2. Atim S.A. et al. (2022). Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda. Journal of Infection, 85(6), 693-701.
  3. Mangombi J.B. et al.(2020). Seroprevalence of Crimean-Congo Hemorrhagic Fever in Domesticated Animals in Northwestern Senegal. Vector-Borne And Zoonotic Diseases, DOI: 20. 10.1089/vbz.2019.2592.

WILDLIFE

  1. BAZ-FLORES S. et al. (2024). Mapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model. Ticks and Tick-borne Diseases, vol. 15, no 1, p. 102281.
  2. Cuadrado-Matias R. et al. (2021). The spatiotemporal dynamics of Crimean-Congo haemorrhagic fever virus in enzootic Iberian scenarios. Poster presented at the Virtual 69th WDA /14th EWDA 2021 Joint Conference Cuenca, Spain.
  3. Espunyes J. et al. (2021). Hotspot of Crimean-Congo Hemorrhagic Fever Virus Seropositivity in Wildlife, Northeastern Spain. Emerging Infectious Diseases, Vol. 27, No. 9.
  4. Peralbo-Moreno A. et al. (2021). Spatial modelling of Hyalomma lusitanicum ticks shape Crimean-Congo haemorrhagic fever virus exposure in Doñana National Park, Spain. Oral presentation at CUENCA 2021, August 31 to September 2, Spain.

HUMANS

  1. Frías M. et al. (2022). The spatial pattern of human exposure to Crimean–Congo haemorrhagic fever virus is not consistent with red deer-based risk predictions. Transboundary and Emerging Diseases, 1–7.
  2. Malonga G.A. et al. (2022). Seroprevalence of Crimean-Congo haemorrhagic fever virus among people living with HIV in Brazzaville, Congo and among blood donors in Bamako, Mali. Poster presented at European Society for Clinical Virology, 7-10 September 2022, Manchester, England.
  3. Matthews J. M. (2022). Sero-epidemiological investigation of Crimean-Congo hemorrhagic fever virus infection in humans and livestock in West Africa. (Doctoral dissertation).
  4. Negredo A. et al. (2021). Retrospective Identification of Early Autochthonous Case of Crimean-Congo Hemorrhagic Fever, Spain, 2013. Emerging Infectious Diseases Vol. 27, No. 6.
  5. Sas M.A. et al. (2018). A novel double-antigen sandwich ELISA for the species-independent detection of Crimean-Congo hemorrhagic fever virus-specific antibodies. Antiviral Research 151, 24-26.
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Associated products

Internal reference material
Freeze-dried CCHF reference serum
ELISA

Freeze-dried immunized goat serum containing antibodies against CCHFV. Read more