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H5 Avian Influenza: the only diagnostic tools to monitor any H5 vaccine and for DIVA strategies

Published on 1 October 2022

Recent and widespread Avian Influenza outbreaks in Europe are prompting authorities to consider introducing H5 vaccination, and in particular the use of recombinant vaccines, to protect flocks from the devastating consequences of the disease. 

IDvet offers the only diagnostic tools to:

  • monitor any H5 vaccine ;
  • differentiate infected and vaccinated animals (DIVA) when recombinant vaccines are used. 

H5 indirect ELISAs for vaccination monitoring

To monitor vaccination with both conventional and recombinant vaccines, IDvet has developed 2 indirect ELISA tests:

IDvet ELISA kit box and reagents

A unique DIVA solution to detect field-infected animals in vaccinated flocks

Chickens, turkeys or geese

If animals are vaccinated with recombinant H5 vaccines, use the ID Screen® Influenza A Nucleoprotein Indirect ELISA (cat. FLUNPS) or the ID Screen® Influenza A Antibody Competition Multi-Species (cat. FLUACA) alongside the “FLUH5S” ELISA to identify field-infected animals in vaccinated flocks as part of a DIVA strategy. This strategy, illustrated in Table 1 below, is only possible with HVT-H5, DNA, mRNA or sub-unit H5 recombinant vaccines.

Table 1: Differentiation between Vaccinated and Infected Animals (for chickens, turkeys or geese)

Ducks

If ducks are vaccinated with recombinant H5 vaccines, use the ID Screen® Influenza A Antibody Competition Multi-Species (cat. FLUACA) alongside the “FLUH5SDUCK” ELISA to identify field-infected ducks in vaccinated flocks as part of a DIVA strategy. This strategy, illustrated in Table 2 below, is only possible with H5 mRNA or sub-unit H5 recombinant vaccines.

Table 2: Differentiation between Vaccinated and Infected Animals (for duck species)

Test features

  • The only quantitative ELISAs on the market for the specific detection of H5 antibodies
  • Specific detection of anti-H5 or anti-nucleoprotein antibodies to differentiate infected from vaccinated animals
  • Monitor both conventional and recombinant vaccines with the “FLUH5S” iELISA (HVT-H5, DNA, mRNA or sub-unit H5 vaccines) and the “FLUH5SDUCK” iELISA (mRNA or sub-unit H5 vaccines)
  • Applicable to a wide range of species:
    • Chickens, turkeys and geese with the “FLUH5S” kit
    • Ducks with the “FLUH5SDUCK” kit

Note: For disease diagnosis in the absence of vaccination, use the ID Screen® Influenza H5 Competition test (cat. FLUACH5) for optimal specificity (for all bird species).

Click here to view the report from a study conducted in France on experimental vaccination in ducks (ANSES): Expérimentation de vaccination des canards mulards en élevage contre un virus influenza aviaire hautement pathogène A(H5N1) clade 2.3.4.4b (anses.fr).